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MGP000251

UniProt Annotations

Entry Information
Gene NameATPase, H+/K+ exchanging, alpha polypeptide
Protein EntryATP4A_HUMAN
UniProt IDP20648
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
FunctionCatalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitComposed of two subunits: alpha (catalytic) and beta.
Tissue SpecificityFound in gastric mucosa.
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