MGP Database

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MGP000255

UniProt Annotations

Entry Information
Gene NameATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Protein EntryATPB_HUMAN
UniProt IDP06576
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
InteractionP63104:YWHAZ; NbExp=2; IntAct=EBI-356231, EBI-347088;
SimilarityBelongs to the ATPase alpha/beta chains family. {ECO:0000305}.
Subcellular LocationMitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
SubunitF-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68. Interacts with PPIF. Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F(1)F(0) ATP synthase and enhances neurons metabolic efficency (By similarity). {ECO:0000250}.
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