MGP Database

MGP000286

Ontology/Pathway Information

Entrez Gene ID	572
Gene Name	BCL2-associated agonist of cell death
Gene Symbol	BAD
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0005741	IDA:UniProtKB	C	mitochondrial outer membrane
GO:0005739	IDA:HPA	C	mitochondrion
GO:0008656	IDA:UniProtKB	F	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008289	IDA:UniProtKB	F	lipid binding
GO:0005543	IMP:UniProtKB	F	phospholipid binding
GO:0019901	IPI:UniProtKB	F	protein kinase binding
GO:0097202	IDA:BHF-UCL	P	activation of cysteine-type endopeptidase activity
GO:0006919	ISS:UniProtKB	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046031	ISS:UniProtKB	P	ADP metabolic process
GO:0006915	IDA:UniProtKB	P	apoptotic process
GO:0097190	TAS:Reactome	P	apoptotic signaling pathway
GO:0046034	ISS:UniProtKB	P	ATP metabolic process
GO:0060154	IEA:Ensembl	P	cellular process regulating host cell cycle in response to virus
GO:0071247	IEA:Ensembl	P	cellular response to chromate
GO:0071456	IEP:UniProtKB	P	cellular response to hypoxia
GO:0071396	IEA:Ensembl	P	cellular response to lipid
GO:0071260	IEP:UniProtKB	P	cellular response to mechanical stimulus
GO:0071316	IDA:UniProtKB	P	cellular response to nicotine
GO:0019221	IEA:Ensembl	P	cytokine-mediated signaling pathway
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0097191	IMP:UniProtKB	P	extrinsic apoptotic signaling pathway
GO:0097192	IEA:Ensembl	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0008625	IEA:Ensembl	P	extrinsic apoptotic signaling pathway via death domain receptors
GO:0038095	TAS:Reactome	P	Fc-epsilon receptor signaling pathway
GO:0008543	TAS:Reactome	P	fibroblast growth factor receptor signaling pathway
GO:0006007	IEA:Ensembl	P	glucose catabolic process
GO:0042593	ISS:UniProtKB	P	glucose homeostasis
GO:0045087	TAS:Reactome	P	innate immune response
GO:0097193	IMP:UniProtKB	P	intrinsic apoptotic signaling pathway
GO:0008630	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0048015	TAS:Reactome	P	phosphatidylinositol-mediated signaling
GO:0046931	IDA:UniProtKB	P	pore complex assembly
GO:0043065	IDA:UniProtKB	P	positive regulation of apoptotic process
GO:0060139	IEA:Ensembl	P	positive regulation of apoptotic process by virus
GO:0010508	TAS:UniProtKB	P	positive regulation of autophagy
GO:0045579	IEA:Ensembl	P	positive regulation of B cell differentiation
GO:0043280	IDA:UniProtKB	P	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050679	IMP:UniProtKB	P	positive regulation of epithelial cell proliferation
GO:0033133	ISS:UniProtKB	P	positive regulation of glucokinase activity
GO:0032024	ISS:UniProtKB	P	positive regulation of insulin secretion
GO:0035774	IEA:Ensembl	P	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:2001244	TAS:Reactome	P	positive regulation of intrinsic apoptotic signaling pathway
GO:0010918	ISS:UniProtKB	P	positive regulation of mitochondrial membrane potential
GO:1901216	IEA:Ensembl	P	positive regulation of neuron death
GO:1900740	TAS:Reactome	P	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0045862	IDA:BHF-UCL	P	positive regulation of proteolysis
GO:0090200	IMP:UniProtKB	P	positive regulation of release of cytochrome c from mitochondria
GO:0045582	IEA:Ensembl	P	positive regulation of T cell differentiation
GO:2000078	ISS:UniProtKB	P	positive regulation of type B pancreatic cell development
GO:0046902	IMP:UniProtKB	P	regulation of mitochondrial membrane permeability
GO:0001836	IEA:Ensembl	P	release of cytochrome c from mitochondria
GO:0043200	IEA:Ensembl	P	response to amino acid
GO:0051592	IEA:Ensembl	P	response to calcium ion
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0034201	IEA:Ensembl	P	response to oleic acid
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0033574	IEA:Ensembl	P	response to testosterone
GO:0019050	IEA:Ensembl	P	suppression by virus of host apoptotic process
GO:0044342	ISS:UniProtKB	P	type B pancreatic cell proliferation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_549	Activation of BAD and translocation to mitochondria
REACT_697	Activation of BH3-only proteins
REACT_75774	Adaptive Immune System
REACT_12564	AKT phosphorylates targets in the cytosol
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_13720	Cell death signalling via NRAGE, NRIF and NADE
REACT_147727	Constitutive PI3K/AKT Signaling in Cancer
REACT_147694	DAP12 interactions
REACT_147814	DAP12 signaling
REACT_116125	Disease
REACT_118638	Downstream signaling events of B Cell Receptor (BCR)
REACT_21272	Downstream signaling of activated FGFR
REACT_17025	Downstream signal transduction
REACT_163936	Fc epsilon receptor (FCERI) signaling
REACT_12578	GAB1 signalosome
REACT_6900	Immune System
REACT_6802	Innate Immune System
REACT_964	Intrinsic Pathway for Apoptosis
REACT_12056	NGF signalling via TRKA from the plasma membrane
REACT_13638	NRAGE signals death through JNK
REACT_13776	p75 NTR receptor-mediated signalling
REACT_12464	PI3K/AKT activation
REACT_147723	PI3K/AKT Signaling in Cancer
REACT_21270	PI-3K cascade
REACT_116008	PI3K events in ERBB2 signaling
REACT_115961	PI3K events in ERBB4 signaling
REACT_75829	PIP3 activates AKT signaling
REACT_268456	Programmed Cell Death
REACT_163769	Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417	Signaling by EGFR
REACT_115871	Signaling by EGFR in Cancer
REACT_268269	Signaling by EGFRvIII in Cancer
REACT_115755	Signaling by ERBB2
REACT_115596	Signaling by ERBB4
REACT_9470	Signaling by FGFR
REACT_120736	Signaling by FGFR in disease
REACT_268006	Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546	Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888	Signaling by PDGF
REACT_111040	Signaling by SCF-KIT
REACT_118773	Signaling by the B Cell Receptor (BCR)
REACT_11061	Signalling by NGF
REACT_111102	Signal Transduction

SMP Pathway Links

SMP ID	Description
SMP00320	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine