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MGP000292

UniProt Annotations

Entry Information
Gene Namebranched chain amino-acid transaminase 1, cytosolic
Protein EntryBCAT1_HUMAN
UniProt IDP54687
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P54687-1; Sequence=Displayed; Name=2; IsoId=P54687-2; Sequence=VSP_042651, VSP_042652; Note=No experimental confirmation available.; Name=3; IsoId=P54687-3; Sequence=VSP_042652; Note=No experimental confirmation available.; Name=4; IsoId=P54687-4; Sequence=VSP_043560; Note=No experimental confirmation available.; Name=5; IsoId=P54687-5; Sequence=VSP_046057; Note=No experimental confirmation available.;
Catalytic ActivityL-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate.
Catalytic ActivityL-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate.
Catalytic ActivityL-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionCatalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
SimilarityBelongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityDuring embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
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