MGP Database

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MGP000311

UniProt Annotations

Entry Information
Gene Namebetaine--homocysteine S-methyltransferase
Protein EntryBHMT1_HUMAN
UniProt IDQ93088
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityTrimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
FunctionInvolved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
PathwayAmine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.
PathwayAmino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.
SimilarityContains 1 Hcy-binding domain. {ECO:0000255|PROSITE- ProRule:PRU00333}.
Subcellular LocationCytoplasm.
SubunitHomotetramer. {ECO:0000269|PubMed:12220488}.
Tissue SpecificityFound exclusively in liver and kidney. {ECO:0000269|PubMed:9281325}.
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