MGP Database

MGP000312

Ontology/Pathway Information

Entrez Gene ID	637
Gene Name	BH3 interacting domain death agonist
Gene Symbol	BID
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0032592	IEA:Ensembl	C	integral component of mitochondrial membrane
GO:0016020	TAS:ProtInc	C	membrane
GO:0005741	TAS:Reactome	C	mitochondrial outer membrane
GO:0005739	TAS:ProtInc	C	mitochondrion
GO:0005123	TAS:ProtInc	F	death receptor binding
GO:0006919	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008637	TAS:ProtInc	P	apoptotic mitochondrial changes
GO:0006915	TAS:Reactome	P	apoptotic process
GO:0007420	IEA:Ensembl	P	brain development
GO:0090150	IDA:BHF-UCL	P	establishment of protein localization to membrane
GO:0008625	TAS:ProtInc	P	extrinsic apoptotic signaling pathway via death domain receptors
GO:0034349	IEA:Ensembl	P	glial cell apoptotic process
GO:0097193	TAS:Reactome	P	intrinsic apoptotic signaling pathway
GO:0051402	TAS:HGNC	P	neuron apoptotic process
GO:0043065	IMP:UniProtKB	P	positive regulation of apoptotic process
GO:2001238	IMP:UniProtKB	P	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	TAS:Reactome	P	positive regulation of intrinsic apoptotic signaling pathway
GO:1901030	TAS:Reactome	P	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0032464	IDA:BHF-UCL	P	positive regulation of protein homooligomerization
GO:1900740	TAS:Reactome	P	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461	IDA:UniProtKB	P	positive regulation of protein oligomerization
GO:0090200	IMP:UniProtKB	P	positive regulation of release of cytochrome c from mitochondria
GO:0051260	IEA:Ensembl	P	protein homooligomerization
GO:0006626	IEA:Ensembl	P	protein targeting to mitochondrion
GO:0042127	IEA:Ensembl	P	regulation of cell proliferation
GO:2000045	IEA:Ensembl	P	regulation of G1/S transition of mitotic cell cycle
GO:1902108	IEA:Ensembl	P	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0001836	IDA:HGNC	P	release of cytochrome c from mitochondria
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0042770	TAS:UniProtKB	P	signal transduction in response to DNA damage

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_707	Activation and oligomerization of BAK protein
REACT_701	Activation, myristolyation of BID and translocation to mitochondria
REACT_549	Activation of BAD and translocation to mitochondria
REACT_697	Activation of BH3-only proteins
REACT_584	Activation, translocation and oligomerization of BAX
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_964	Intrinsic Pathway for Apoptosis
REACT_268456	Programmed Cell Death