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MGP000319

UniProt Annotations

Entry Information
Gene NameBMI1 proto-oncogene, polycomb ring finger
Protein EntryBMI1_HUMAN
UniProt IDP35226
SpeciesHuman
Comments
Comment typeDescription
FunctionComponent of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984}.
InteractionO00257:CBX4; NbExp=4; IntAct=EBI-2341576, EBI-722425; O00257-3:CBX4; NbExp=2; IntAct=EBI-2341576, EBI-4392727; O95503:CBX6; NbExp=3; IntAct=EBI-2341576, EBI-3951758; O95931:CBX7; NbExp=7; IntAct=EBI-2341576, EBI-3923843; Q9HC52:CBX8; NbExp=13; IntAct=EBI-2341576, EBI-712912; P60484:PTEN; NbExp=3; IntAct=EBI-2341576, EBI-696162; Q06587:RING1; NbExp=11; IntAct=EBI-2341576, EBI-752313; Q99496:RNF2; NbExp=9; IntAct=EBI-2341576, EBI-722416; P0CG48:UBC; NbExp=2; IntAct=EBI-2341576, EBI-3390054; P51784:USP11; NbExp=7; IntAct=EBI-2341576, EBI-306876; Q93009:USP7; NbExp=7; IntAct=EBI-2341576, EBI-302474; Q9H270:VPS11; NbExp=2; IntAct=EBI-2341576, EBI-373380;
MiscellaneousThe hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
PtmMonoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:15897469}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular LocationNucleus. Cytoplasm.
SubunitComponent of a PRC1-like complex. Interacts with RING1 and RING2 (By similarity). Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. {ECO:0000250, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:9121482, ECO:0000269|PubMed:9199346}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BMI1ID807ch10p12.html";
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