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MGP000342

UniProt Annotations

Entry Information
Gene NameKruppel-like factor 5 (intestinal)
Protein EntryKLF5_HUMAN
UniProt IDQ13887
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13887-1; Sequence=Displayed; Name=2; IsoId=Q13887-2; Sequence=VSP_047474; Name=3; IsoId=Q13887-3; Sequence=VSP_047475, VSP_047476;
FunctionTranscription factor that binds to GC box promoter elements. Activates the transcription of these genes.
InteractionP0CG48:UBC; NbExp=2; IntAct=EBI-2696013, EBI-3390054;
PtmUbiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. {ECO:0000269|PubMed:15735697}.
SimilarityBelongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.
SimilarityContains 3 C2H2-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00042}.
Subcellular LocationNucleus {ECO:0000269|PubMed:15735697}.
SubunitInteracts with WWP1. {ECO:0000269|PubMed:15735697}.
Tissue SpecificityExpressed only in testis and placenta.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/KLF5ID41074ch13q21.html";
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