MGP Database

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MGP000343

Ontology/Pathway Information

Entrez Gene ID695
Gene NameBruton agammaglobulinemia tyrosine kinase
Gene Symbol BTK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0045121 IDA:HGNCCmembrane raft
GO:0005634 TAS:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005524 TAS:HGNCFATP binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004715 TAS:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0005547 IDA:UniProtKBFphosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713 TAS:HGNCFprotein tyrosine kinase activity
GO:0002250 TAS:UniProtKBPadaptive immune response
GO:0097190 TAS:ProtIncPapoptotic signaling pathway
GO:0042113 TAS:UniProtKBPB cell activation
GO:0050853 TAS:UniProtKBPB cell receptor signaling pathway
GO:0019722 TAS:HGNCPcalcium-mediated signaling
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0035556 TAS:HGNCPintracellular signal transduction
GO:0007498 TAS:ProtIncPmesoderm development
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0018108 EXP:GOCPpeptidyl-tyrosine phosphorylation
GO:0045579 TAS:UniProtKBPpositive regulation of B cell differentiation
GO:0051092 TAS:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0006468 TAS:HGNCPprotein phosphorylation
GO:0002902 TAS:UniProtKBPregulation of B cell apoptotic process
GO:0002721 TAS:UniProtKBPregulation of B cell cytokine production
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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