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MGP000348

Record overview

MGPD IDMGP000348
Gene ID712
SpeciesHomo sapiens (Human)
Gene Namecomplement component 1, q subcomponent, A chain
Gene Symbol C1QA
Alternate namescomplement C1q subcomponent subunit A; complement component C1q, A chain; complement component 1, q subcomponent, alpha polypeptide;
Chromosome1
Map Location1p36.12
SummaryThis gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for C1QA

Proteins

complement C1q subcomponent subunit A precursor
Refseq ID:NP_057075
Protein GI:7705753
UniProt ID:P02745
mRNA ID:NM_015991
Length:245
RefSeq Status:
MEGPRGWLVLCVLAISLASMVTEDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIK
GTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQV
VSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2347
peptide sequence: 
MEGPRGWLVLCVLAISLASMVT
 
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