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MGP000349

Record overview

MGPD IDMGP000349
Gene ID713
SpeciesHomo sapiens (Human)
Gene Namecomplement component 1, q subcomponent, B chain
Gene Symbol C1QB
Alternate namescomplement C1q subcomponent subunit B; complement component C1q, B chain; complement subcomponent C1q chain B; complement component 1, q subcomponent, beta polypeptide;
Chromosome1
Map Location1p36.12
SummaryThis gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for C1QB

Proteins

complement C1q subcomponent subunit B precursor
Refseq ID:NP_000482
Protein GI:87298828
UniProt ID:P02746
mRNA ID:NM_000491
Length:253
RefSeq Status:
MMMKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGG
PGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDY
AYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA
 
sig_peptide: 1..27
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2998
peptide sequence: 
MMMKIPWGSIPVLMLLLLLGLIDISQA
 
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