MGP Database

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MGP000350

Record overview

MGPD IDMGP000350
Gene ID714
SpeciesHomo sapiens (Human)
Gene Namecomplement component 1, q subcomponent, C chain
Gene Symbol C1QC
SynonymsC1QG; C1Q-C;
Alternate namescomplement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide;
Chromosome1
Map Location1p36.11
SummaryThis gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for C1QC

Proteins

complement C1q subcomponent subunit C precursor
Refseq ID:NP_001107573
Protein GI:166235903
UniProt ID:P02747
mRNA ID:NM_001114101
Length:245
RefSeq Status:
MDVGPSSLPHLGLKLLLLLLLLPLRGQANTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPG
PMGIPGEPGEEGRYKQKFQSVFTVTRQTHQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTN
QVNSGGVLLRLQVGEEVWLAVNDYYDMVGIQGSDSVFSGFLLFPD
 
sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2979
peptide sequence: 
MDVGPSSLPHLGLKLLLLLLLLPLRGQA

mat_peptide: 29..245
product: complement C1q subcomponent subunit C
calculated_mol_wt: 22813
peptide sequence: 
NTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQT
HQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMV
GIQGSDSVFSGFLLFPD

sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2979
peptide sequence: 
MDVGPSSLPHLGLKLLLLLLLLPLRGQA

mat_peptide: 29..245
product: complement C1q subcomponent subunit C
calculated_mol_wt: 22813
peptide sequence: 
NTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQT
HQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMV
GIQGSDSVFSGFLLFPD
 
complement C1q subcomponent subunit C precursor
Refseq ID:NP_758957
Protein GI:56786155
UniProt ID:P02747
mRNA ID:NM_172369
Length:245
RefSeq Status:
Protein sequence is identical to GI:166235903 (mRNA isoform)
 
sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2979
peptide sequence: 
MDVGPSSLPHLGLKLLLLLLLLPLRGQA

mat_peptide: 29..245
product: complement C1q subcomponent subunit C
calculated_mol_wt: 22813
peptide sequence: 
NTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQT
HQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMV
GIQGSDSVFSGFLLFPD
 
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