MGP Database

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MGP000354

Ontology/Pathway Information

Entrez Gene ID718
Gene Namecomplement component 3
Gene Symbol C3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031715 IDA:UniProtKBFC5L2 anaphylatoxin chemotactic receptor binding
GO:0004866 IEA:InterProFendopeptidase inhibitor activity
GO:0005102 TAS:ProtIncFreceptor binding
GO:0006956 IMP:BHF-UCLPcomplement activation
GO:0006957 TAS:ReactomePcomplement activation, alternative pathway
GO:0006958 IEA:UniProtKB-KWPcomplement activation, classical pathway
GO:0006631 IEA:UniProtKB-KWPfatty acid metabolic process
GO:0007186 TAS:ProtIncPG-protein coupled receptor signaling pathway
GO:0006955 TAS:ProtIncPimmune response
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0001970 IEA:EnsemblPpositive regulation of activation of membrane attack complex
GO:0045766 IEA:EnsemblPpositive regulation of angiogenesis
GO:2000427 IMP:BHF-UCLPpositive regulation of apoptotic cell clearance
GO:0010828 IDA:UniProtKBPpositive regulation of glucose transport
GO:0045745 IDA:UniProtKBPpositive regulation of G-protein coupled receptor protein signaling pathway
GO:0010884 IDA:UniProtKBPpositive regulation of lipid storage
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0001798 IEA:EnsemblPpositive regulation of type IIa hypersensitivity
GO:0010575 IDA:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0030449 TAS:ReactomePregulation of complement activation
GO:0050776 TAS:ReactomePregulation of immune response
GO:0010866 IDA:UniProtKBPregulation of triglyceride biosynthetic process
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_7972Activation of C3 and C5
REACT_75774Adaptive Immune System
REACT_8001Alternative complement activation
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_6932Complement cascade
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_6900Immune System
REACT_11152Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_8024Initial triggering of complement
REACT_6802Innate Immune System
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_118707Regulation of Complement cascade
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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