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MGP000355

UniProt Annotations

Entry Information
Gene Namecomplement component 3a receptor 1
Protein EntryC3AR_HUMAN
UniProt IDQ16581
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
PtmAmong the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. {ECO:0000269|PubMed:12871936}.
PtmO-glycosylated. {ECO:0000269|PubMed:23234360}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityWidely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/c3ar1/";
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