MGP Database

MGP000360

Ontology/Pathway Information

Entrez Gene ID	727
Gene Name	complement component 5
Gene Symbol	C5
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	TAS:ProtInc	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005579	IEA:UniProtKB-KW	C	membrane attack complex
GO:0008009	TAS:ProtInc	F	chemokine activity
GO:0004866	IEA:InterPro	F	endopeptidase inhibitor activity
GO:0005102	TAS:ProtInc	F	receptor binding
GO:0000187	TAS:ProtInc	P	activation of MAPK activity
GO:0060326	TAS:GOC	P	cell chemotaxis
GO:0007166	TAS:ProtInc	P	cell surface receptor signaling pathway
GO:0006874	IEA:Ensembl	P	cellular calcium ion homeostasis
GO:0006935	TAS:ProtInc	P	chemotaxis
GO:0006956	TAS:Reactome	P	complement activation
GO:0006957	IEA:UniProtKB-KW	P	complement activation, alternative pathway
GO:0006958	IEA:UniProtKB-KW	P	complement activation, classical pathway
GO:0019835	IEA:UniProtKB-KW	P	cytolysis
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0007186	TAS:ProtInc	P	G-protein coupled receptor signaling pathway
GO:0006954	TAS:ProtInc	P	inflammatory response
GO:0045087	TAS:Reactome	P	innate immune response
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0002523	IEA:Ensembl	P	leukocyte migration involved in inflammatory response
GO:0033602	IEA:Ensembl	P	negative regulation of dopamine secretion
GO:0010760	IDA:BHF-UCL	P	negative regulation of macrophage chemotaxis
GO:0010700	IEA:Ensembl	P	negative regulation of norepinephrine secretion
GO:0045766	IEA:Ensembl	P	positive regulation of angiogenesis
GO:0090197	IDA:BHF-UCL	P	positive regulation of chemokine secretion
GO:0050921	IEA:Ensembl	P	positive regulation of chemotaxis
GO:0010575	IDA:BHF-UCL	P	positive regulation vascular endothelial growth factor production
GO:0030449	TAS:Reactome	P	regulation of complement activation
GO:0006950	TAS:ProtInc	P	response to stress

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_7972	Activation of C3 and C5
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_6932	Complement cascade
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19231	G alpha (i) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_6900	Immune System
REACT_6802	Innate Immune System
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_118707	Regulation of Complement cascade
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction
REACT_8028	Terminal pathway of complement