MGP Database

MGP000361

Ontology/Pathway Information

Entrez Gene ID	728
Gene Name	complement component 5a receptor 1
Gene Symbol	C5AR1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0045177	IDA:UniProtKB	C	apical part of cell
GO:0016323	IDA:UniProtKB	C	basolateral plasma membrane
GO:0009986	IEA:Ensembl	C	cell surface
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0004944	IDA:UniProtKB	F	C5a anaphylatoxin receptor activity
GO:0004878	IDA:UniProtKB	F	complement component C5a receptor activity
GO:0000187	TAS:ProtInc	P	activation of MAPK activity
GO:0007202	TAS:ProtInc	P	activation of phospholipase C activity
GO:0006915	IEA:Ensembl	P	apoptotic process
GO:0021534	IEA:Ensembl	P	cell proliferation in hindbrain
GO:0006968	TAS:ProtInc	P	cellular defense response
GO:0006935	TAS:ProtInc	P	chemotaxis
GO:0038178	IDA:GOC	P	complement component C5a signaling pathway
GO:0050830	IEA:Ensembl	P	defense response to Gram-positive bacterium
GO:0006955	TAS:ProtInc	P	immune response
GO:0006954	IEA:Ensembl	P	inflammatory response
GO:0042789	IDA:UniProtKB	P	mRNA transcription from RNA polymerase II promoter
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:0030593	IEA:Ensembl	P	neutrophil chemotaxis
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0007204	TAS:ProtInc	P	positive regulation of cytosolic calcium ion concentration
GO:0050679	IDA:UniProtKB	P	positive regulation of epithelial cell proliferation
GO:0070374	IDA:UniProtKB	P	positive regulation of ERK1 and ERK2 cascade
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0032494	IEA:Ensembl	P	response to peptidoglycan
GO:0007606	TAS:ProtInc	P	sensory perception of chemical stimulus
GO:0007165	TAS:ProtInc	P	signal transduction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19231	G alpha (i) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction