MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000370

Record overview

MGPD IDMGP000370
Gene ID759
SpeciesHomo sapiens (Human)
Gene Namecarbonic anhydrase I
Gene Symbol CA1
SynonymsCAB; CA-I; Car1; HEL-S-11;
Alternate namescarbonic anhydrase 1; carbonic anhydrase B; carbonate dehydratase I; epididymis secretory protein Li 11;
Chromosome8
Map Location8q21.2
EC Number4.2.1.1
SummaryCarbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
OrthologsView orthologs and multiple alignments for CA1

Proteins

carbonic anhydrase 1 isoform a
Refseq ID:NP_001122301
Protein GI:192447430
UniProt ID:P00915
mRNA ID:NM_001128829
Length:261
RefSeq Status:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGS
TNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLT
HPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
 
carbonic anhydrase 1 isoform a
Refseq ID:NP_001729
Protein GI:4502517
UniProt ID:P00915
mRNA ID:NM_001738
Length:261
RefSeq Status:
Protein sequence is identical to GI:192447430 (mRNA isoform)
 
carbonic anhydrase 1 isoform a
Refseq ID:NP_001122303
Protein GI:192447434
UniProt ID:P00915
mRNA ID:NM_001128831
Length:261
RefSeq Status:
Protein sequence is identical to GI:192447430 (mRNA isoform)
 
carbonic anhydrase 1 isoform a
Refseq ID:NP_001122302
Protein GI:192447432
UniProt ID:P00915
mRNA ID:NM_001128830
Length:261
RefSeq Status:
Protein sequence is identical to GI:192447430 (mRNA isoform)
 
carbonic anhydrase 1 isoform a
Refseq ID:NP_001158302
Protein GI:258679498
UniProt ID:P00915
mRNA ID:NM_001164830
Length:261
RefSeq Status:
Protein sequence is identical to GI:192447430 (mRNA isoform)
 
carbonic anhydrase 1 isoform b
Refseq ID:NP_001278896
Protein GI:634743300
UniProt ID:
mRNA ID:NM_001291967
Length:195
RefSeq Status:
MASPDWGYDDKNVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQ
AIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
 
carbonic anhydrase 1 isoform c
Refseq ID:NP_001278897
Protein GI:634743302
UniProt ID:
mRNA ID:NM_001291968
Length:148
RefSeq Status:
MMTKMLHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIIC
KESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
 
  logo