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MGP000373

Record overview

MGPD IDMGP000373
Gene ID762
SpeciesHomo sapiens (Human)
Gene Namecarbonic anhydrase IV
Gene Symbol CA4
SynonymsCAIV; Car4; RP17;
Alternate namescarbonic anhydrase 4; CA-IV; carbonic dehydratase IV; carbonate dehydratase IV;
Chromosome17
Map Location17q23
EC Number4.2.1.1
SummaryCarbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CA4

Proteins

carbonic anhydrase 4 precursor
Refseq ID:NP_000708
Protein GI:4502519
UniProt ID:P22748
mRNA ID:NM_000717
Length:312
RefSeq Status:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASI
SGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMA
ESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
 
sig_peptide: 1..18
calculated_mol_wt: 1872
peptide sequence: 
MRMLLALLALSAARPSAS

mat_peptide: 19..312
product: carbonic anhydrase 4
calculated_mol_wt: 33178
peptide sequence: 
AESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW
SDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYF
RYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
 
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