MGP Database

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MGP000381

Ontology/Pathway Information

Entrez Gene ID775
Gene Namecalcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Symbol CACNA1C
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0002095 IEA:EnsemblCcaveolar macromolecular signaling complex
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0043198 IEA:EnsemblCdendritic shaft
GO:0016021 IDA:UniProtKBCintegral component of membrane
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0014069 IDA:UniProtKBCpostsynaptic density
GO:0005891 IDA:UniProtKBCvoltage-gated calcium channel complex
GO:0030018 ISS:BHF-UCLCZ disc
GO:0051393 IPI:BHF-UCLFalpha-actinin binding
GO:0005516 IPI:UniProtKBFcalmodulin binding
GO:0008331 IBA:RefGenomeFhigh voltage-gated calcium channel activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0005245 IDA:UniProtKBFvoltage-gated calcium channel activity
GO:0007628 IEA:EnsemblPadult walking behavior
GO:0007411 TAS:ReactomePaxon guidance
GO:0017156 IEA:EnsemblPcalcium ion-dependent exocytosis
GO:0070509 IBA:RefGenomePcalcium ion import
GO:0060402 TAS:BHF-UCLPcalcium ion transport into cytosol
GO:0035585 TAS:BHF-UCLPcalcium-mediated signaling using extracellular calcium source
GO:0086064 TAS:BHF-UCLPcell communication by electrical coupling involved in cardiac conduction
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0042593 IEA:EnsemblPglucose homeostasis
GO:0030252 IEA:EnsemblPgrowth hormone secretion
GO:0030073 IEA:EnsemblPinsulin secretion
GO:0086010 IBA:RefGenomePmembrane depolarization during action potential
GO:0007204 IDA:UniProtKBPpositive regulation of cytosolic calcium ion concentration
GO:0008217 IEA:EnsemblPregulation of blood pressure
GO:0010881 TAS:BHF-UCLPregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0046620 IEA:EnsemblPregulation of organ growth
GO:0019229 IEA:EnsemblPregulation of vasoconstriction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0060083 IEA:EnsemblPsmooth muscle contraction involved in micturition
GO:0007268 IEA:EnsemblPsynaptic transmission
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_18266Axon guidance
REACT_111045Developmental Biology
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_18312NCAM1 interactions
REACT_18334NCAM signaling for neurite out-growth
REACT_18325Regulation of insulin secretion
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00619Felodipine Metabolism Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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