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MGP000386

UniProt Annotations

Entry Information
Gene Namecalcium channel, voltage-dependent, beta 1 subunit
Protein EntryCACB1_HUMAN
UniProt IDQ02641
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Beta-1b2, BetaA, Beta-1B, Beta1-2; IsoId=Q02641-1; Sequence=Displayed; Name=2; Synonyms=Beta-1M, BetaC, Beta-1a; IsoId=Q02641-2; Sequence=VSP_000623, VSP_000624, VSP_000625; Name=3; Synonyms=Beta-1b1, BetaB, Beta-1c, Beta1-3; IsoId=Q02641-3; Sequence=VSP_000624, VSP_000625;
FunctionThe beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Sequence CautionSequence=CAA79825.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the calcium channel beta subunit family. {ECO:0000305}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
SubunitThe L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 (By similarity). {ECO:0000250}.
Tissue SpecificityIsoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. {ECO:0000269|PubMed:8107964}.
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