MGP Database

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MGP000391

Ontology/Pathway Information

Entrez Gene ID790
Gene Namecarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Gene Symbol CAD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0042995 ISS:BHF-UCLCcell projection
GO:0005829 IDA:BHF-UCLCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0043025 ISS:BHF-UCLCneuronal cell body
GO:0016363 IDA:BHF-UCLCnuclear matrix
GO:0005634 IDA:BHF-UCLCnucleus
GO:0043234 IEA:EnsemblCprotein complex
GO:0043195 ISS:BHF-UCLCterminal bouton
GO:0070335 ISS:BHF-UCLFaspartate binding
GO:0004070 ISS:BHF-UCLFaspartate carbamoyltransferase activity
GO:0005524 ISS:BHF-UCLFATP binding
GO:0004088 ISS:BHF-UCLFcarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151 IDA:UniProtKBFdihydroorotase activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042802 ISS:BHF-UCLFidentical protein binding
GO:0004672 ISS:BHF-UCLFprotein kinase activity
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0070409 IEA:InterProPcarbamoyl phosphate biosynthetic process
GO:0035690 IEA:EnsemblPcellular response to drug
GO:0071364 IEA:EnsemblPcellular response to epidermal growth factor stimulus
GO:0006207 IDA:UniProtKBP'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205 IEA:UniProtKB-UniPathwayP'de novo' UMP biosynthetic process
GO:0017144 ISS:BHF-UCLPdrug metabolic process
GO:0007565 IEA:EnsemblPfemale pregnancy
GO:0006543 IEA:InterProPglutamine catabolic process
GO:0006541 ISS:BHF-UCLPglutamine metabolic process
GO:0007507 IEA:EnsemblPheart development
GO:0007595 IEA:EnsemblPlactation
GO:0001889 IEA:EnsemblPliver development
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0018107 ISS:BHF-UCLPpeptidyl-threonine phosphorylation
GO:0046777 ISS:BHF-UCLPprotein autophosphorylation
GO:0006206 TAS:ReactomePpyrimidine nucleobase metabolic process
GO:0046134 TAS:ReactomePpyrimidine nucleoside biosynthetic process
GO:0014075 IEA:EnsemblPresponse to amine
GO:0031000 IEA:EnsemblPresponse to caffeine
GO:0051414 IEA:EnsemblPresponse to cortisol
GO:0033574 IEA:EnsemblPresponse to testosterone
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006228 IEA:EnsemblPUTP biosynthetic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_21376Pyrimidine biosynthesis
REACT_957Pyrimidine metabolism
SMP Pathway Links
SMP IDDescription
SMP001362-Hydroxyglutric Aciduria (D And L Form)
SMP002434-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
SMP00067Aspartate Metabolism
SMP00172Beta Ureidopropionase Deficiency
SMP00175Canavan Disease
SMP00178Dihydropyrimidinase Deficiency
SMP00072Glutamate Metabolism
SMP00385Homocarnosinosis
SMP00339Hyperinsulinism-Hyperammonemia Syndrome
SMP00192Hypoacetylaspartia
SMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
SMP00046Pyrimidine Metabolism
SMP00567Succinic semialdehyde dehydrogenase deficiency
SMP00219UMP Synthase Deiciency (Orotic Aciduria)
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