MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000405

Record overview

MGPD IDMGP000405
Gene ID820
SpeciesHomo sapiens (Human)
Gene Namecathelicidin antimicrobial peptide
Gene Symbol CAMP
SynonymsLL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39;
Alternate namescathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein;
Chromosome3
Map Location3p21.3
SummaryThis gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
OrthologsView orthologs and multiple alignments for CAMP

Proteins

cathelicidin antimicrobial peptide preproprotein
Refseq ID:NP_004336
Protein GI:348041314
UniProt ID:P49913
mRNA ID:NM_004345
Length:173
RefSeq Status:
MGTMKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDC
DFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
 
sig_peptide: 1..33
inference: protein motif:SignalP:3.0
note: The cleavage site of the signal peptide has not been experimentally determined.
calculated_mol_wt: 3592
peptide sequence: 
MGTMKTQRDGHSLGRWSLVLLLLGLVMPLAIIA

mat_peptide: 135..173
product: FALL-39
experiment: DESCRIPTION:antimicrobial activity[PMID: 7529412]
exception: alternative processing
calculated_mol_wt: 4712
peptide sequence: 
FALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

mat_peptide: 136..173
product: ALL-38
experiment: DESCRIPTION:antimicrobial activity[PMID: 12759353]
calculated_mol_wt: 4564
peptide sequence: 
ALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

mat_peptide: 137..173
product: LL-37
experiment: DESCRIPTION:antimicrobial activity[PMID: 9182550]
exception: alternative processing
calculated_mol_wt: 4493
peptide sequence: 
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

mat_peptide: 137..165
product: LL-29
experiment: DESCRIPTION:antimicrobial activity[PMID: 17012259]
calculated_mol_wt: 3596
peptide sequence: 
LLGDFFRKSKEKIGKEFKRIVQRIKDFLR

mat_peptide: 137..159
product: LL-23
experiment: DESCRIPTION:antimicrobial activity[PMID: 17012259]
exception: alternative processing
calculated_mol_wt: 2823
peptide sequence: 
LLGDFFRKSKEKIGKEFKRIVQR

mat_peptide: 143..173
product: RK-31
experiment: DESCRIPTION:antimicrobial activity[PMID: 14978112]
calculated_mol_wt: 3801
peptide sequence: 
RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

mat_peptide: 144..173
product: KS-30
experiment: DESCRIPTION:This protein/peptide has antimicrobial activity[PMID: 14978112]
exception: alternative processing
calculated_mol_wt: 3644
peptide sequence: 
KSKEKIGKEFKRIVQRIKDFLRNLVPRTES

mat_peptide: 144..170
product: KS-27
experiment: DESCRIPTION:antimicrobial peptide[PMID: 17012259]
calculated_mol_wt: 3327
peptide sequence: 
KSKEKIGKEFKRIVQRIKDFLRNLVPR

mat_peptide: 144..165
product: KS-22
experiment: DESCRIPTION:antimicrobial activity[PMID: 17012259]
exception: alternative processing
calculated_mol_wt: 2747
peptide sequence: 
KSKEKIGKEFKRIVQRIKDFLR

mat_peptide: 154..173
product: KR-20
experiment: DESCRIPTION:antimicrobial peptide[PMID: 14978112]
exception: alternative processing
calculated_mol_wt: 2469
peptide sequence: 
KRIVQRIKDFLRNLVPRTES
 
  logo