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MGP000412

UniProt Annotations

Entry Information
Gene Namecysteinyl-tRNA synthetase
Protein EntrySYCC_HUMAN
UniProt IDP49589
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P49589-1; Sequence=Displayed; Name=2; IsoId=P49589-2; Sequence=VSP_006312; Note=Found in 20% of the mRNAs.; Name=3; IsoId=P49589-3; Sequence=VSP_043571; Note=Contains a phosphoserine at position 79.;
Catalytic ActivityATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
DiseaseNote=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
Sequence CautionSequence=AAA73901.1; Type=Frameshift; Positions=619; Evidence={ECO:0000305};
SimilarityBelongs to the class-I aminoacyl-tRNA synthetase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000250}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CARSID484.html";
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