MGP Database

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MGP000421

Ontology/Pathway Information

Entrez Gene ID843
Gene Namecaspase 10, apoptosis-related cysteine peptidase
Gene Symbol CASP10
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031265 IDA:UniProtKBCCD95 death-inducing signaling complex
GO:0005737 IBA:RefGenomeCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005886 TAS:ReactomeCplasma membrane
GO:0097342 IDA:UniProtKBCripoptosome
GO:0004197 TAS:ProtIncFcysteine-type endopeptidase activity
GO:0097199 IMP:UniProtKBFcysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0035877 IPI:UniProtKBFdeath effector domain binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0006915 IBA:RefGenomePapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0043123 IMP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042981 IEA:InterProPregulation of apoptotic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1619Death Receptor Signalling
REACT_1059Extrinsic Pathway
REACT_900FasL/ CD95L signaling
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_268456Programmed Cell Death
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_402TRAIL signaling
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