MGP Database

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MGP000422

UniProt Annotations

Entry Information
Gene Namecalsequestrin 1 (fast-twitch, skeletal muscle)
Protein EntryCASQ1_HUMAN
UniProt IDP31415
SpeciesHuman
Comments
Comment typeDescription
FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. {ECO:0000269|PubMed:22337878, ECO:0000303|PubMed:22337878}.
PtmN-glycosylated. {ECO:0000250|UniProtKB:P07221}.
Sequence CautionSequence=AAB32063.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22289.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36060.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the calsequestrin family. {ECO:0000305}.
Subcellular LocationSarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. {ECO:0000250|UniProtKB:P07221}.
SubunitInteracts with ASPH and TRDN (By similarity). Monomer, homodimer, homotetramer and homopolymer. Can form linear homooligomers. Ca(2+) ions promote oligomerization. {ECO:0000250|UniProtKB:P07221, ECO:0000269|PubMed:22337878}.
Web ResourceName=Wikipedia; Note=Calsequestrin entry; URL="http://en.wikipedia.org/wiki/Calsequestrin";
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