MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000441

UniProt Annotations

Entry Information
Gene Namecyclin D2
Protein EntryCCND2_HUMAN
UniProt IDP30279
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P30279-1; Sequence=Displayed; Name=2; Synonyms=Truncated; IsoId=P30279-2; Sequence=VSP_057295, VSP_057296; Note=Acts as proto-oncogene. Retains ability to bind CDK4, but unable to catalyze efficiently RB phosphorylation and inactivation. {ECO:0000269|PubMed:17873913};
FunctionRegulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
InteractionP38936:CDKN1A; NbExp=3; IntAct=EBI-748789, EBI-375077;
PtmPolyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. {ECO:0000269|PubMed:22323446}.
SimilarityBelongs to the cyclin family. Cyclin D subfamily. {ECO:0000305}.
SimilarityContains 1 cyclin N-terminal domain. {ECO:0000305}.
Subcellular LocationIsoform 2: Cytoplasm {ECO:0000269|PubMed:17873913}.
Subcellular LocationNucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
SubunitInteracts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. {ECO:0000269|PubMed:18827403}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnd2/";
  logo