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MGP000448

UniProt Annotations

Entry Information
Gene NameCD2 molecule
Protein EntryCD2_HUMAN
UniProt IDP06729
SpeciesHuman
Comments
Comment typeDescription
FunctionCD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
InteractionQ9Y5K6:CD2AP; NbExp=4; IntAct=EBI-3912464, EBI-298152; O95400:CD2BP2; NbExp=3; IntAct=EBI-3912464, EBI-768015; Q96B97:SH3KBP1; NbExp=3; IntAct=EBI-3912464, EBI-346595;
SimilarityContains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitInteracts with CD2AP (By similarity). Interacts with PSTPIP1. {ECO:0000250, ECO:0000269|PubMed:9857189}.
Web ResourceName=Wikipedia; Note=CD2 entry; URL="http://en.wikipedia.org/wiki/CD2";
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