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MGP000455

UniProt Annotations

Entry Information
Gene NameCD9 molecule
Protein EntryCD9_HUMAN
UniProt IDP21926
SpeciesHuman
Comments
Comment typeDescription
FunctionInvolved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. {ECO:0000269|PubMed:14575715, ECO:0000269|PubMed:7511626, ECO:0000269|PubMed:8478605}.
InteractionP08473:MME; NbExp=6; IntAct=EBI-4280101, EBI-353759;
PtmPalmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. {ECO:0000269|PubMed:11959120}.
SimilarityBelongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Cell membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}.
SubunitForms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts with CD63. Identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8. {ECO:0000269|PubMed:11278880, ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:14556650, ECO:0000269|PubMed:19640571}.
Tissue SpecificityDetected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells. {ECO:0000269|PubMed:19640571}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CD9ID995ch12p13.html";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cd9/";
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