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MGP000474

Record overview

MGPD IDMGP000474
Gene ID975
SpeciesHomo sapiens (Human)
Gene NameCD81 molecule
Gene Symbol CD81
SynonymsS5.7; CVID6; TAPA1; TSPAN28;
Alternate namesCD81 antigen; tspan-28; tetraspanin-28; 26 kDa cell surface protein TAPA-1; CD81 antigen (target of antiproliferative antibody 1);
Chromosome11
Map Location11p15.5
SummaryThe protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
OrthologsView orthologs and multiple alignments for CD81

Proteins

CD81 antigen isoform 1
Refseq ID:NP_004347
Protein GI:4757944
UniProt ID:P60033
mRNA ID:NM_004356
Length:236
RefSeq Status:
MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVI
LFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSG
KLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
 
CD81 antigen isoform 2
Refseq ID:NP_001284578
Protein GI:663071018
UniProt ID:P60033
mRNA ID:NM_001297649
Length:165
RefSeq Status:
MMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLK
NNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
 
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