MGP Database

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MGP000475

UniProt Annotations

Entry Information
Gene NameCD97 molecule
Protein EntryCD97_HUMAN
UniProt IDP48960
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=EGF(1,2,3,4,5); IsoId=P48960-1; Sequence=Displayed; Name=2; Synonyms=EGF(1,2,5); IsoId=P48960-2; Sequence=VSP_009411; Name=3; Synonyms=EGF(1,2,3,5); IsoId=P48960-3; Sequence=VSP_009412;
DomainBinding to chondroitin sulfate is mediated by the fourth EGF domain.
DomainThe first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
FunctionReceptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). {ECO:0000250}.
InductionRapid up-regulation during lymphocyte activation.
PtmProteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. {ECO:0000250}.
Sequence CautionSequence=AAC27673.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC06178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. {ECO:0000305}.
SimilarityContains 1 GPS domain. {ECO:0000255|PROSITE- ProRule:PRU00098}.
SimilarityContains 5 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Subcellular LocationCD97 antigen subunit alpha: Secreted, extracellular space.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitForms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven- transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate. {ECO:0000269|PubMed:11297558, ECO:0000269|PubMed:12829604}.
Tissue SpecificityBroadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CD97ID996ch19p13.html";
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