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MGP000477

Record overview

MGPD IDMGP000477
Gene ID978
SpeciesHomo sapiens (Human)
Gene Namecytidine deaminase
Gene Symbol CDA
SynonymsCDD;
Alternate namescytidine deaminase; cytidine aminohydrolase; small cytidine deaminase; cytosine nucleoside deaminase;
Chromosome1
Map Location1p36.2-p35
EC Number3.5.4.5
SummaryThis gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CDA

Proteins

cytidine deaminase
Refseq ID:NP_001776
Protein GI:11386157
UniProt ID:P32320
mRNA ID:NM_001785
Length:146
RefSeq Status:
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCG
ACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ
 
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