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MGP000478

Record overview

MGPD IDMGP000478
Gene ID983
SpeciesHomo sapiens (Human)
Gene Namecyclin-dependent kinase 1
Gene Symbol CDK1
SynonymsCDC2; CDC28A; P34CDC2;
Alternate namescyclin-dependent kinase 1; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; p34 protein kinase;
Chromosome10
Map Location10q21.1
EC Number2.7.11.22
SummaryThe protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for CDK1

Proteins

cyclin-dependent kinase 1 isoform 1
Refseq ID:NP_001777
Protein GI:4502709
UniProt ID:P06493
mRNA ID:NM_001786
Length:297
RefSeq Status:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYM
DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATK
KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
 
cyclin-dependent kinase 1 isoform 2
Refseq ID:NP_203698
Protein GI:16306492
UniProt ID:P06493
mRNA ID:NM_033379
Length:240
RefSeq Status:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYM
DSSLVKVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD
ENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
 
cyclin-dependent kinase 1 isoform 4
Refseq ID:NP_001163877
Protein GI:281427278
UniProt ID:B7Z3D6
mRNA ID:NM_001170406
Length:109
RefSeq Status:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYM
DSSLVKVKA
 
cyclin-dependent kinase 1 isoform 4
Refseq ID:NP_001163878
Protein GI:281427280
UniProt ID:B7Z3D6
mRNA ID:NM_001170407
Length:109
RefSeq Status:
Protein sequence is identical to GI:281427278 (mRNA isoform)
 
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