MGP Database

MGP000489

Ontology/Pathway Information

Entrez Gene ID	999
Gene Name	cadherin 1, type 1, E-cadherin (epithelial)
Gene Symbol	CDH1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0015629	IDA:BHF-UCL	C	actin cytoskeleton
GO:0016235	IDA:HPA	C	aggresome
GO:0043296	IDA:UniProtKB	C	apical junction complex
GO:0045177	IEA:Ensembl	C	apical part of cell
GO:0043679	IEA:Ensembl	C	axon terminus
GO:0016323	IEA:Ensembl	C	basolateral plasma membrane
GO:0016342	IDA:BHF-UCL	C	catenin complex
GO:0005913	IDA:BHF-UCL	C	cell-cell adherens junction
GO:0030054	TAS:UniProtKB	C	cell junction
GO:0009986	IEA:Ensembl	C	cell surface
GO:0005737	IDA:HPA	C	cytoplasm
GO:0009898	IDA:UniProtKB	C	cytoplasmic side of plasma membrane
GO:0005768	IEA:UniProtKB-SubCell	C	endosome
GO:0005576	TAS:Reactome	C	extracellular region
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005925	IDA:HPA	C	focal adhesion
GO:0016021	IDA:BHF-UCL	C	integral component of membrane
GO:0043219	IEA:Ensembl	C	lateral loop
GO:0016328	IDA:BHF-UCL	C	lateral plasma membrane
GO:0033268	IEA:Ensembl	C	node of Ranvier
GO:0048471	IDA:BHF-UCL	C	perinuclear region of cytoplasm
GO:0005886	IDA:HPA	C	plasma membrane
GO:0043220	IEA:Ensembl	C	Schmidt-Lanterman incisure
GO:0005802	IMP:BHF-UCL	C	trans-Golgi network
GO:0030506	IPI:BHF-UCL	F	ankyrin binding
GO:0008013	IDA:BHF-UCL	F	beta-catenin binding
GO:0005509	IEA:Ensembl	F	calcium ion binding
GO:0050839	IPI:UniProtKB	F	cell adhesion molecule binding
GO:0045295	IPI:BHF-UCL	F	gamma-catenin binding
GO:0001948	IPI:UniProtKB	F	glycoprotein binding
GO:0032794	IPI:UniProtKB	F	GTPase activating protein binding
GO:0034332	IMP:UniProtKB	P	adherens junction organization
GO:0006915	TAS:Reactome	P	apoptotic process
GO:0016339	IEA:Ensembl	P	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0045216	TAS:Reactome	P	cell-cell junction organization
GO:0034329	TAS:Reactome	P	cell junction assembly
GO:0006921	TAS:Reactome	P	cellular component disassembly involved in execution phase of apoptosis
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0071681	IDA:UniProtKB	P	cellular response to indole-3-methanol
GO:0071285	IDA:UniProtKB	P	cellular response to lithium ion
GO:0090102	IEA:Ensembl	P	cochlea development
GO:0003382	IEA:Ensembl	P	epithelial cell morphogenesis
GO:0090002	IMP:UniProtKB	P	establishment of protein localization to plasma membrane
GO:0022617	TAS:Reactome	P	extracellular matrix disassembly
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0007156	NAS:UniProtKB	P	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0060576	IEA:Ensembl	P	intestinal epithelial cell development
GO:0090090	IEA:Ensembl	P	negative regulation of canonical Wnt signaling pathway
GO:0022408	IMP:UniProtKB	P	negative regulation of cell-cell adhesion
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0031175	IEA:Ensembl	P	neuron projection development
GO:0021983	IEA:Ensembl	P	pituitary gland development
GO:0045893	IDA:BHF-UCL	P	positive regulation of transcription, DNA-templated
GO:0042993	IDA:BHF-UCL	P	positive regulation of transcription factor import into nucleus
GO:0051260	IEA:Ensembl	P	protein homooligomerization
GO:0072659	IDA:BHF-UCL	P	protein localization to plasma membrane
GO:0019538	IEA:Ensembl	P	protein metabolic process
GO:0060693	IEA:Ensembl	P	regulation of branching involved in salivary gland morphogenesis
GO:0043281	IEA:Ensembl	P	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050776	TAS:Reactome	P	regulation of immune response
GO:2001222	IEA:Ensembl	P	regulation of neuron migration
GO:2000008	IEA:Ensembl	P	regulation of protein localization to cell surface
GO:0033561	IEA:Ensembl	P	regulation of water loss via skin
GO:0042493	IEA:Ensembl	P	response to drug
GO:0009636	IEA:Ensembl	P	response to toxic substance
GO:0060662	IEA:Ensembl	P	salivary gland cavitation
GO:0007605	IEA:Ensembl	P	sensory perception of sound
GO:0016337	IDA:BHF-UCL	P	single organismal cell-cell adhesion
GO:0007416	IEA:Ensembl	P	synapse assembly
GO:0070830	IEA:Ensembl	P	tight junction assembly
GO:0001829	IEA:Ensembl	P	trophectodermal cell differentiation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75774	Adaptive Immune System
REACT_19195	Adherens junctions interactions
REACT_578	Apoptosis
REACT_13579	Apoptotic cleavage of cell adhesion proteins
REACT_107	Apoptotic cleavage of cellular proteins
REACT_995	Apoptotic execution phase
REACT_111155	Cell-Cell communication
REACT_19331	Cell-cell junction organization
REACT_20676	Cell junction organization
REACT_118572	Degradation of the extracellular matrix
REACT_118779	Extracellular matrix organization
REACT_6900	Immune System
REACT_11152	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_13552	Integrin cell surface interactions
REACT_268456	Programmed Cell Death