MGP Database

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MGP000493

UniProt Annotations

Entry Information
Gene Namecadherin 5, type 2 (vascular endothelium)
Protein EntryCADH5_HUMAN
UniProt IDP33151
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33151-1; Sequence=Displayed; Name=2; IsoId=P33151-2; Sequence=VSP_053861; Note=No experimental confirmation available.;
DomainThree calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.
InteractionP35222:CTNNB1; NbExp=6; IntAct=EBI-2903122, EBI-491549; Q8TEW0:PARD3; NbExp=5; IntAct=EBI-2903122, EBI-81968; Q9NPB6:PARD6A; NbExp=4; IntAct=EBI-2903122, EBI-81876;
PtmO-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:21269602}.
PtmPhosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity). {ECO:0000250}.
SimilarityContains 5 cadherin domains. {ECO:0000255|PROSITE- ProRule:PRU00043}.
Subcellular LocationCell junction {ECO:0000269|PubMed:20332120}. Cell membrane {ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
SubunitInteracts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3 (By similarity). {ECO:0000250}.
Tissue SpecificityEndothelial tissues and brain.
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