MGP Database

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MGP000494

UniProt Annotations

Entry Information
Gene Namecadherin 6, type 2, K-cadherin (fetal kidney)
Protein EntryCADH6_HUMAN
UniProt IDP55285
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55285-1; Sequence=Displayed; Name=2; IsoId=P55285-2; Sequence=VSP_000636, VSP_000637;
DomainThree calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
SimilarityContains 5 cadherin domains. {ECO:0000255|PROSITE- ProRule:PRU00043}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
Tissue SpecificityHighly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
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