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MGP000499

UniProt Annotations

Entry Information
Gene Namecadherin 11, type 2, OB-cadherin (osteoblast)
Protein EntryCAD11_HUMAN
UniProt IDP55287
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55287-1; Sequence=Displayed; Name=2; IsoId=P55287-2; Sequence=VSP_000640, VSP_000641;
DiseaseNote=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
DomainThree calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
SimilarityContains 5 cadherin domains. {ECO:0000255|PROSITE- ProRule:PRU00043}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
SubunitInteracts with PCDH8. {ECO:0000250}.
Tissue SpecificityExpressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
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