MGP Database

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MGP000501

UniProt Annotations

Entry Information
Gene Namecadherin 13
Protein EntryCAD13_HUMAN
UniProt IDP55290
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P55290-1; Sequence=Displayed; Name=2; IsoId=P55290-2; Sequence=VSP_042696, VSP_042697; Name=3; IsoId=P55290-3; Sequence=VSP_042794, VSP_042795; Name=4; IsoId=P55290-4; Sequence=VSP_046714; Note=Gene prediction based on EST data.; Name=5; IsoId=P55290-5; Sequence=VSP_053739; Note=No experimental confirmation available.;
Developmental StageExpressed at higher levels in adult brain than in developing brain. {ECO:0000269|PubMed:10737605}.
DomainThree calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.
SimilarityContains 5 cadherin domains. {ECO:0000255|PROSITE- ProRule:PRU00043}.
Subcellular LocationCell membrane; Lipid-anchor, GPI-anchor.
SubunitBy contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape. {ECO:0000250}.
Tissue SpecificityHighly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord. {ECO:0000269|PubMed:10737605, ECO:0000269|PubMed:8673923}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDH13ID40018ch16q23.html";
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