MGP Database

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MGP000506

Ontology/Pathway Information

Entrez Gene ID1019
Gene Namecyclin-dependent kinase 4
Gene Symbol CDK4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000785 IDA:UniProtKBCchromatin
GO:0000307 IDA:UniProtKBCcyclin-dependent protein kinase holoenzyme complex
GO:0005829 IDA:UniProtKBCcytosol
GO:0031965 IDA:UniProtKBCnuclear membrane
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005923 IEA:EnsemblCtight junction
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0030332 IPI:UniProtKBFcyclin binding
GO:0004693 IDA:BHF-UCLFcyclin-dependent protein serine/threonine kinase activity
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0007623 IEA:EnsemblPcircadian rhythm
GO:0000082 IMP:BHF-UCLPG1/S transition of mitotic cell cycle
GO:0002088 IEA:EnsemblPlens development in camera-type eye
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0071157 IDA:UniProtKBPnegative regulation of cell cycle arrest
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0008284 IMP:BHF-UCLPpositive regulation of cell proliferation
GO:0045793 IEA:EnsemblPpositive regulation of cell size
GO:0048146 IMP:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0010971 IDA:UniProtKBPpositive regulation of G2/M transition of mitotic cell cycle
GO:0045727 IEA:EnsemblPpositive regulation of translation
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:0010468 IMP:BHF-UCLPregulation of gene expression
GO:0042493 IGI:UniProtKBPresponse to drug
GO:0055093 IEA:EnsemblPresponse to hyperoxia
GO:0010288 IEA:EnsemblPresponse to lead ion
GO:0033574 IEA:EnsemblPresponse to testosterone
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0007165 IEA:EnsemblPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_821Cyclin D associated events in G1
REACT_111045Developmental Biology
REACT_1590G1 Phase
REACT_111183Meiosis
REACT_27271Meiotic recombination
REACT_21267Mitotic G1-G1/S phases
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_264545RMTs methylate histone arginines
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_899S Phase
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_938Ubiquitin-dependent degradation of Cyclin D
REACT_4Ubiquitin-dependent degradation of Cyclin D1
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