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MGP000518

UniProt Annotations

Entry Information

Gene Name	cysteine dioxygenase type 1
Protein Entry	CDO1_HUMAN
UniProt ID	Q16878
Species	Human

Comments

Comment type	Description
Catalytic Activity	L-cysteine + O(2) = 3-sulfinoalanine.
Cofactor	Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) cation per subunit. Zn(2+) can be used to a much lesser extent.;
Function	Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
Induction	In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA). {ECO:0000269\|PubMed:10427686}.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Ptm	The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
Similarity	Belongs to the cysteine dioxygenase family. {ECO:0000305}.
Subunit	Monomer. {ECO:0000269\|PubMed:17135237}.
Tissue Specificity	Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. {ECO:0000269\|PubMed:10427686}.