MGP Database

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MGP000519

UniProt Annotations

Entry Information
Gene NameCDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Protein EntryCDS1_HUMAN
UniProt IDQ92903
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCTP + phosphatidate = diphosphate + CDP- diacylglycerol.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionProvides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
SimilarityBelongs to the CDS family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.
SubunitInteracts with FOS; this interaction may enhance catalytic activity. {ECO:0000250}.
Tissue SpecificityExpressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.
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