MGP Database

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MGP000523

UniProt Annotations

Entry Information
Gene NameCCAAT/enhancer binding protein (C/EBP), delta
Protein EntryCEBPD_HUMAN
UniProt IDP49716
SpeciesHuman
Comments
Comment typeDescription
FunctionC/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.
SimilarityBelongs to the bZIP family. C/EBP subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
Subcellular LocationNucleus.
SubunitBinds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1. Interacts with PRDM16 (By similarity). {ECO:0000250}.
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