MGP Database

MGP000532

Record overview

MGPD ID	MGP000532
Gene ID	1075
Species	Homo sapiens (Human)
Gene Name	cathepsin C
Gene Symbol	CTSC
Synonyms	JP; HMS; JPD; PLS; CPPI; DPP1; DPPI; PALS; DPP-I; PDON1;
Alternate names	dipeptidyl peptidase 1; cathepsin J; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase I;
Chromosome	11
Map Location	11q14.2
EC Number	3.4.14.1
Summary	The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for CTSC

Proteins

dipeptidyl peptidase 1 isoform a preproprotein

Refseq ID:	NP_001805
Protein GI:	189083844
UniProt ID:	P53634
mRNA ID:	NM_001814
Length:	463
RefSeq Status:

MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYK
WFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGD
MIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPF
ELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2312
peptide sequence: 
MGAGPSLLLAALLLLLSGDGAVRC

mat_peptide: 231..394
product: cathepsin C heavy chain
calculated_mol_wt: 18473
peptide sequence: 
LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSP
CKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLR

mat_peptide: 395..463
product: cathepsin C light chain
exception: alternative processing
calculated_mol_wt: 7578
peptide sequence: 
DPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL

dipeptidyl peptidase 1 isoform b precursor

Refseq ID:	NP_680475
Protein GI:	22538440
UniProt ID:	P53634
mRNA ID:	NM_148170
Length:	137
RefSeq Status:

`MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYK WFAFFKDVTDFISHLFMQLGTVGIYDLPHLRNKLVIK`

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2312
peptide sequence: 
MGAGPSLLLAALLLLLSGDGAVRC

mat_peptide: 231..394
product: cathepsin C heavy chain
calculated_mol_wt: 18473
peptide sequence: 
LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSP
CKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLR

mat_peptide: 395..463
product: cathepsin C light chain
exception: alternative processing
calculated_mol_wt: 7578
peptide sequence: 
DPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2312
peptide sequence: 
MGAGPSLLLAALLLLLSGDGAVRC

mat_peptide: 25..141
product: dipeptidyl peptidase 1 isoform c
calculated_mol_wt: 13406
peptide sequence: 
DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKDVTDFISHLFMQLGTVGI
YDLPHLRNKLAMNRRWG

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2312
peptide sequence: 
MGAGPSLLLAALLLLLSGDGAVRC

mat_peptide: 25..137
product: dipeptidyl peptidase 1 isoform b
calculated_mol_wt: 12875
peptide sequence: 
DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKDVTDFISHLFMQLGTVGI
YDLPHLRNKLVIK

dipeptidyl peptidase 1 isoform c precursor

Refseq ID:	NP_001107645
Protein GI:	167000671
UniProt ID:	P53634
mRNA ID:	NM_001114173
Length:	141
RefSeq Status:

`MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYK WFAFFKDVTDFISHLFMQLGTVGIYDLPHLRNKLAMNRRWG`

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2312
peptide sequence: 
MGAGPSLLLAALLLLLSGDGAVRC

mat_peptide: 231..394
product: cathepsin C heavy chain
calculated_mol_wt: 18473
peptide sequence: 
LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSP
CKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLR

mat_peptide: 395..463
product: cathepsin C light chain
exception: alternative processing
calculated_mol_wt: 7578
peptide sequence: 
DPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2312
peptide sequence: 
MGAGPSLLLAALLLLLSGDGAVRC

mat_peptide: 25..141
product: dipeptidyl peptidase 1 isoform c
calculated_mol_wt: 13406
peptide sequence: 
DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKDVTDFISHLFMQLGTVGI
YDLPHLRNKLAMNRRWG