MGP Database

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MGP000533

Ontology/Pathway Information

Entrez Gene ID1080
Gene Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Symbol CFTR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 IDA:UniProtKBCapical plasma membrane
GO:0016323 NAS:UniProtKBCbasolateral plasma membrane
GO:0009986 IDA:UniProtKBCcell surface
GO:0034707 IEA:UniProtKB-KWCchloride channel complex
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0030659 IEA:EnsemblCcytoplasmic vesicle membrane
GO:0005769 IDA:UniProtKBCearly endosome
GO:0031901 IEA:UniProtKB-SubCellCearly endosome membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005902 IEA:EnsemblCmicrovillus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0043234 IDA:UniProtKBCprotein complex
GO:0055037 IDA:UniProtKBCrecycling endosome
GO:0005524 TAS:ProtIncFATP binding
GO:0005224 TAS:ProtIncFATP-binding and phosphorylation-dependent chloride channel activity
GO:0015106 ISS:UniProtKBFbicarbonate transmembrane transporter activity
GO:0005260 NAS:UniProtKBFchannel-conductance-controlling ATPase activity
GO:0005254 IDA:UniProtKBFchloride channel activity
GO:0019869 IDA:UniProtKBFchloride channel inhibitor activity
GO:0015108 ISS:UniProtKBFchloride transmembrane transporter activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0030165 IDA:UniProtKBFPDZ domain binding
GO:0071320 ISS:UniProtKBPcellular response to cAMP
GO:0032870 IEA:EnsemblPcellular response to hormone stimulus
GO:1902476 IDA:GOCPchloride transmembrane transport
GO:0006695 IEA:EnsemblPcholesterol biosynthetic process
GO:0030301 IEA:EnsemblPcholesterol transport
GO:0051454 ISS:UniProtKBPintracellular pH elevation
GO:0015705 IEA:EnsemblPiodide transport
GO:0030324 IEA:EnsemblPlung development
GO:0060081 ISS:UniProtKBPmembrane hyperpolarization
GO:0045909 IEA:EnsemblPpositive regulation of vasodilation
GO:1902943 IDA:UniProtKBPpositive regulation of voltage-gated chloride channel activity
GO:0007585 TAS:ProtIncPrespiratory gaseous exchange
GO:0034097 IEA:EnsemblPresponse to cytokine
GO:0042493 IEA:EnsemblPresponse to drug
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0048240 ISS:UniProtKBPsperm capacitation
GO:0030321 IEA:EnsemblPtransepithelial chloride transport
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0006810 TAS:ProtIncPtransport
GO:0042311 IEA:EnsemblPvasodilation
GO:0006833 IEA:EnsemblPwater transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15480ABC-family proteins mediated transport
REACT_15518Transmembrane transport of small molecules
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