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MGP000534

Record overview

MGPD IDMGP000534
Gene ID1081
SpeciesHomo sapiens (Human)
Gene Nameglycoprotein hormones, alpha polypeptide
Gene Symbol CGA
SynonymsHCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA;
Alternate namesglycoprotein hormones alpha chain; FSH-alpha; LSH-alpha; TSH-alpha; lutropin alpha chain; follitropin alpha chain; thyrotropin alpha chain; choriogonadotropin alpha chain; luteinizing hormone alpha chain; chorionic gonadotrophin subunit alpha; thyroid-stimulating hormone alpha chain; follicle-stimulating hormone alpha chain; chorionic gonadotropin, alpha polypeptide; follicle-stimulating hormone alpha subunit; anterior pituitary glycoprotein hormones common subunit alpha;
Chromosome6
Map Location6q12-q21
SummaryThe four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
OrthologsView orthologs and multiple alignments for CGA

Proteins

glycoprotein hormones alpha chain isoform 1 precursor
Refseq ID:NP_001239312
Protein GI:356874784
UniProt ID:P01215
mRNA ID:NM_001252383
Length:147
RefSeq Status:
MDYYRKYAAIFLVTLSVFLHVLHSAPDVQETGFHHVAQAALKLLSSSNPPTKASQSARITDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKK
TMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2887
peptide sequence: 
MDYYRKYAAIFLVTLSVFLHVLHS

mat_peptide: 25..147
product: glycoprotein hormones alpha chain isoform 1
calculated_mol_wt: 13436
peptide sequence: 
APDVQETGFHHVAQAALKLLSSSNPPTKASQSARITDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVT
VMGGFKVENHTACHCSTCYYHKS
 
glycoprotein hormones alpha chain isoform 2 precursor
Refseq ID:NP_000726
Protein GI:4502787
UniProt ID:P01215
mRNA ID:NM_000735
Length:116
RefSeq Status:
MDYYRKYAAIFLVTLSVFLHVLHSAPDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKV
ENHTACHCSTCYYHKS
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2887
peptide sequence: 
MDYYRKYAAIFLVTLSVFLHVLHS

mat_peptide: 25..147
product: glycoprotein hormones alpha chain isoform 1
calculated_mol_wt: 13436
peptide sequence: 
APDVQETGFHHVAQAALKLLSSSNPPTKASQSARITDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVT
VMGGFKVENHTACHCSTCYYHKS

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2887
peptide sequence: 
MDYYRKYAAIFLVTLSVFLHVLHS

mat_peptide: 25..116
product: glycoprotein hormones alpha chain isoform 2
calculated_mol_wt: 10206
peptide sequence: 
APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
 
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