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MGP000539

UniProt Annotations

Entry Information
Gene Namechromodomain helicase DNA binding protein 3
Protein EntryCHD3_HUMAN
UniProt IDQ12873
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q12873-1; Sequence=Displayed; Name=2; IsoId=Q12873-2; Sequence=VSP_017231; Name=3; IsoId=Q12873-3; Sequence=VSP_047097; Note=No experimental confirmation available. Gene prediction based on EST data.;
Catalytic ActivityATP + H(2)O = ADP + phosphate.
FunctionComponent of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.
InteractionQ99728:BARD1; NbExp=2; IntAct=EBI-523590, EBI-473181; P17844:DDX5; NbExp=4; IntAct=EBI-523590, EBI-351962; Q9Y2X7:GIT1; NbExp=2; IntAct=EBI-523590, EBI-466061; P42858:HTT; NbExp=3; IntAct=EBI-523590, EBI-466029; O60341:KDM1A; NbExp=4; IntAct=EBI-523590, EBI-710124; O75400:PRPF40A; NbExp=2; IntAct=EBI-523590, EBI-473291; Q8NC51:SERBP1; NbExp=5; IntAct=EBI-523590, EBI-523558; P61956:SUMO2; NbExp=3; IntAct=EBI-523590, EBI-473220;
MiscellaneousOne of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.
Sequence CautionSequence=AAB87383.1; Type=Miscellaneous discrepancy; Note=Differs from position 1967 onward for unknown reasons.; Evidence={ECO:0000305};
SimilarityBelongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
SimilarityContains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00541}.
SimilarityContains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00542}.
SimilarityContains 2 chromo domains. {ECO:0000255|PROSITE- ProRule:PRU00053}.
SimilarityContains 2 PHD-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00146}.
Subcellular LocationNucleus {ECO:0000269|PubMed:17626165}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase and mitosis.
SubunitCentral component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts (via its C-terminal) with HABP4. Interacts with PCNT; the interaction regulates centrosome integrity. {ECO:0000269|PubMed:11230151, ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:17626165}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:9688266}.
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