MGP Database

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MGP000546

Record overview

MGPD IDMGP000546
Gene ID1123
SpeciesHomo sapiens (Human)
Gene Namechimerin 1
Gene Symbol CHN1
SynonymsNC; CHN; DURS2; ARHGAP2; RHOGAP2;
Alternate namesN-chimaerin; n-chimerin; A-chimaerin; chimaerin 1; a2-chimaerin; alpha-chimerin; chimerin (chimaerin) 1; Rho GTPase-activating protein 2;
Chromosome2
Map Location2q31.1
SummaryThis gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
OrthologsView orthologs and multiple alignments for CHN1

Proteins

N-chimaerin isoform 1
Refseq ID:NP_001813
Protein GI:4502813
UniProt ID:P15882
mRNA ID:NM_001822
Length:459
RefSeq Status:
MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYD
GKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIP
KYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE
GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAH
LKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
 
N-chimaerin isoform 2
Refseq ID:NP_001020372
Protein GI:209364623
UniProt ID:P15882
mRNA ID:NM_001025201
Length:433
RefSeq Status:
MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYD
GKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRVHTFRGPHWCEYCANFM
WGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKA
DISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTL
MRSPELDAMAALNDIRYQRLVVELLIKNEDILF
 
N-chimaerin isoform 3
Refseq ID:NP_001193531
Protein GI:331028583
UniProt ID:P15882
mRNA ID:NM_001206602
Length:334
RefSeq Status:
MPSKESWSGRKTNRAAVHKSKQEGRQQDLLIAALGMKLGSPKSSVTIWQPLKLFAYSQLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANF
MWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEK
ADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPT
LMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
 
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