MGP Database

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MGP000556

Ontology/Pathway Information

Entrez Gene ID1137
Gene Namecholinergic receptor, nicotinic, alpha 4 (neuronal)
Gene Symbol CHRNA4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005892 IDA:UniProtKBCacetylcholine-gated channel complex
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0030425 ISS:UniProtKBCdendrite
GO:0009897 ISS:UniProtKBCexternal side of plasma membrane
GO:0016021 NAS:UniProtKBCintegral component of membrane
GO:0016020 ISS:UniProtKBCmembrane
GO:0043025 ISS:UniProtKBCneuronal cell body
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0045211 IEA:UniProtKB-SubCellCpostsynaptic membrane
GO:0004889 IDA:UniProtKBFacetylcholine-activated cation-selective channel activity
GO:0042166 IC:UniProtKBFacetylcholine binding
GO:0015464 IDA:UniProtKBFacetylcholine receptor activity
GO:0015276 TAS:DFLATFligand-gated ion channel activity
GO:0001508 ISS:UniProtKBPaction potential
GO:0042113 ISS:UniProtKBPB cell activation
GO:0035095 IMP:UniProtKBPbehavioral response to nicotine
GO:0006816 ISS:UniProtKBPcalcium ion transport
GO:0098655 IDA:GOCPcation transmembrane transport
GO:0050890 IMP:UniProtKBPcognition
GO:0006281 IMP:UniProtKBPDNA repair
GO:0035640 IEA:EnsemblPexploration behavior
GO:0034220 TAS:GOCPion transmembrane transport
GO:0006811 NAS:UniProtKBPion transport
GO:0007626 IEA:EnsemblPlocomotory behavior
GO:0051899 ISS:UniProtKBPmembrane depolarization
GO:0050877 IMP:UniProtKBPneurological system process
GO:0014059 ISS:UniProtKBPregulation of dopamine secretion
GO:0060080 ISS:UniProtKBPregulation of inhibitory postsynaptic membrane potential
GO:0042391 ISS:UniProtKBPregulation of membrane potential
GO:0007585 IEA:EnsemblPrespiratory gaseous exchange
GO:0001666 IDA:UniProtKBPresponse to hypoxia
GO:0035094 IDA:UniProtKBPresponse to nicotine
GO:0006979 IMP:UniProtKBPresponse to oxidative stress
GO:0019233 ISS:UniProtKBPsensory perception of pain
GO:0007165 IDA:UniProtKBPsignal transduction
GO:0007268 NAS:UniProtKBPsynaptic transmission
GO:0007271 ISS:UniProtKBPsynaptic transmission, cholinergic
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15461Acetylcholine Binding And Downstream Events
REACT_22126Activation of Nicotinic Acetylcholine Receptors
REACT_22352Highly calcium permeable nicotinic acetylcholine receptors
REACT_22303Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
REACT_22223Highly sodium permeable acetylcholine nicotinic receptors
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_22149Postsynaptic nicotinic acetylcholine receptors
REACT_22336Presynaptic nicotinic acetylcholine receptors
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00628Nicotine Metabolism Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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