MGP Database

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MGP000559

Ontology/Pathway Information

Entrez Gene ID1141
Gene Namecholinergic receptor, nicotinic, beta 2 (neuronal)
Gene Symbol CHRNB2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005892 IDA:UniProtKBCacetylcholine-gated channel complex
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0009897 ISS:UniProtKBCexternal side of plasma membrane
GO:0016021 NAS:UniProtKBCintegral component of membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0045211 IEA:UniProtKB-SubCellCpostsynaptic membrane
GO:0004889 IDA:UniProtKBFacetylcholine-activated cation-selective channel activity
GO:0042166 IMP:UniProtKBFacetylcholine binding
GO:0015464 IDA:UniProtKBFacetylcholine receptor activity
GO:0008144 IEA:EnsemblFdrug binding
GO:0015276 TAS:DFLATFligand-gated ion channel activity
GO:0001508 IEA:EnsemblPaction potential
GO:0008306 ISS:UniProtKBPassociative learning
GO:0042113 ISS:UniProtKBPB cell activation
GO:0035095 IMP:UniProtKBPbehavioral response to nicotine
GO:0006816 ISS:UniProtKBPcalcium ion transport
GO:0098655 IDA:GOCPcation transmembrane transport
GO:0021952 ISS:UniProtKBPcentral nervous system projection neuron axonogenesis
GO:0050890 IMP:UniProtKBPcognition
GO:0001661 IEA:EnsemblPconditioned taste aversion
GO:0034220 TAS:GOCPion transmembrane transport
GO:0006811 NAS:UniProtKBPion transport
GO:0021771 ISS:UniProtKBPlateral geniculate nucleus development
GO:0007612 IMP:UniProtKBPlearning
GO:0007626 ISS:UniProtKBPlocomotory behavior
GO:0051899 ISS:UniProtKBPmembrane depolarization
GO:0007613 IMP:UniProtKBPmemory
GO:0045759 ISS:UniProtKBPnegative regulation of action potential
GO:0050877 IMP:UniProtKBPneurological system process
GO:0021631 ISS:UniProtKBPoptic nerve morphogenesis
GO:0030890 ISS:UniProtKBPpositive regulation of B cell proliferation
GO:0033603 ISS:UniProtKBPpositive regulation of dopamine secretion
GO:0032226 IEA:EnsemblPpositive regulation of synaptic transmission, dopaminergic
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0045188 IEA:EnsemblPregulation of circadian sleep/wake cycle, non-REM sleep
GO:0042320 ISS:UniProtKBPregulation of circadian sleep/wake cycle, REM sleep
GO:0048814 ISS:UniProtKBPregulation of dendrite morphogenesis
GO:0042053 ISS:UniProtKBPregulation of dopamine metabolic process
GO:0014059 ISS:UniProtKBPregulation of dopamine secretion
GO:0051963 ISS:UniProtKBPregulation of synapse assembly
GO:0032225 ISS:UniProtKBPregulation of synaptic transmission, dopaminergic
GO:0042220 ISS:UniProtKBPresponse to cocaine
GO:0045471 ISS:UniProtKBPresponse to ethanol
GO:0001666 IDA:UniProtKBPresponse to hypoxia
GO:0035094 IDA:UniProtKBPresponse to nicotine
GO:0019233 ISS:UniProtKBPsensory perception of pain
GO:0007605 ISS:UniProtKBPsensory perception of sound
GO:0007165 IDA:UniProtKBPsignal transduction
GO:0006939 ISS:UniProtKBPsmooth muscle contraction
GO:0035176 ISS:UniProtKBPsocial behavior
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0007271 ISS:UniProtKBPsynaptic transmission, cholinergic
GO:0060084 ISS:UniProtKBPsynaptic transmission involved in micturition
GO:0021562 ISS:UniProtKBPvestibulocochlear nerve development
GO:0008542 IMP:UniProtKBPvisual learning
GO:0007601 ISS:UniProtKBPvisual perception
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15461Acetylcholine Binding And Downstream Events
REACT_22126Activation of Nicotinic Acetylcholine Receptors
REACT_22352Highly calcium permeable nicotinic acetylcholine receptors
REACT_22303Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
REACT_22223Highly sodium permeable acetylcholine nicotinic receptors
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_22149Postsynaptic nicotinic acetylcholine receptors
REACT_22336Presynaptic nicotinic acetylcholine receptors
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00628Nicotine Metabolism Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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