MGP Database

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MGP000565

Ontology/Pathway Information

Entrez Gene ID1147
Gene Nameconserved helix-loop-helix ubiquitous kinase
Gene Symbol CHUK
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0035631 ISS:BHF-UCLCCD40 receptor complex
GO:0005737 IDA:HPACcytoplasm
GO:0009898 ISS:BHF-UCLCcytoplasmic side of plasma membrane
GO:0005829 TAS:ReactomeCcytosol
GO:0008385 TAS:UniProtKBCIkappaB kinase complex
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0005634 IDA:HPACnucleus
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008384 TAS:UniProtKBFIkappaB kinase activity
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0097110 IDA:MGIFscaffold protein binding
GO:0009653 TAS:ProtIncPanatomical structure morphogenesis
GO:0071356 IDA:UniProtKBPcellular response to tumor necrosis factor
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0007249 TAS:UniProtKBPI-kappaB kinase/NF-kappaB signaling
GO:0007252 TAS:ProtIncPI-kappaB phosphorylation
GO:0006955 TAS:ProtIncPimmune response
GO:0006954 TAS:UniProtKBPinflammatory response
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0007595 IEA:EnsemblPlactation
GO:0060749 IEA:EnsemblPmammary gland alveolus development
GO:0033598 IEA:EnsemblPmammary gland epithelial cell proliferation
GO:0002011 IEA:EnsemblPmorphogenesis of an epithelial sheet
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423 TAS:ReactomePnucleotide-binding oligomerization domain containing signaling pathway
GO:0042475 IEA:EnsemblPodontogenesis of dentin-containing tooth
GO:0030316 IEA:EnsemblPosteoclast differentiation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0043123 TAS:ReactomePpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092 TAS:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0043200 IEA:EnsemblPresponse to amino acid
GO:0042493 IEA:EnsemblPresponse to drug
GO:0033194 IEA:EnsemblPresponse to hydroperoxide
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0009615 TAS:UniProtKBPresponse to virus
GO:0007266 IEA:EnsemblPRho protein signal transduction
GO:0003009 IEA:EnsemblPskeletal muscle contraction
GO:0051146 IEA:EnsemblPstriated muscle cell differentiation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_75790Cytokine Signaling in Immune system
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_12578GAB1 signalosome
REACT_25374IKK complex recruitment mediated by RIP1
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22442Interleukin-1 signaling
REACT_24918IRAK1 recruits IKK complex
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_12526TCR signaling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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