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MGP000568

UniProt Annotations

Entry Information
Gene Nametubulin folding cofactor B
Protein EntryTBCB_HUMAN
UniProt IDQ99426
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99426-1; Sequence=Displayed; Name=2; IsoId=Q99426-2; Sequence=VSP_055521; Note=No experimental confirmation available.;
FunctionBinds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
InteractionQ9H2C0:GAN; NbExp=3; IntAct=EBI-764356, EBI-764342; Q93009:USP7; NbExp=2; IntAct=EBI-764356, EBI-302474;
PtmPhosphorylation by PAK1 is required for normal function. {ECO:0000269|PubMed:15144186, ECO:0000269|PubMed:15592455, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:17525332}.
PtmUbiquitinated in the presence of GAN which targets it for degradation by the proteasome. {ECO:0000250}.
Sequence CautionSequence=AAB51182.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the TBCB family. {ECO:0000305}.
SimilarityContains 1 CAP-Gly domain. {ECO:0000255|PROSITE- ProRule:PRU00045}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:15831477}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15831477}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
SubunitSupercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Binds to GAN. {ECO:0000269|PubMed:16303566}.
Tissue SpecificityFound in most tissues.
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